精神疾病的多基因风险和特定学科的学校成绩
Oskar Hougaard Jefsen1, Katrine Holde2, John J McGrath3
1Psychosis Research Unit, Aarhus University Hospital, Psychiatry, Aarhus, Denmark; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Biological psychiatry
|December 7, 2023
概括
对注意力缺陷/多动症的遗传倾向与较低的学年级有关,而对神经性厌食症和双相情感障碍的风险与更高的学年级有关. 心理健康多基因风险评分显示与学业成绩有不同的关联.
科学领域:
- 精神病学遗传学 精神病学遗传学
- 教育心理学教育心理学
- 行为遗传学 行为遗传学
背景情况:
- 精神障碍显著影响教育轨迹,尽管复杂的遗传相关性.
- 由于观察到的异质性,了解心理健康和教育之间的遗传重叠至关重要.
研究的目的:
- 调查6种精神障碍与特定教育成果之间的差异性遗传关联.
- 探索心理健康和学业表现之间的遗传重叠的异质性.
主要方法:
- 使用了全国代表性的队列数据 (N=79,489).
- 计算了6种精神疾病的多基因风险评分.
- 检查了与九年级和高中语文和数学成绩的关联,以及到25岁时的教育成就.
主要成果:
- 与较低的语言和数学成绩相关的注意力缺陷/多动性障碍 (ADHD) 的高多基因风险.
- 与较高的语言和数学成绩相关的精神厌食症和双相情感障碍的高多基因风险.
- 对精神分裂症和严重抑郁症观察到混合的关联;对于自闭症谱系障碍中性.
结论:
- 精神疾病的多基因风险评分与语言和数学学业绩有差异性关联.
- 对某些精神障碍的遗传责任以疾病特定的方式影响教育成果.
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