对HeartMate 3风险评分的多中心评估
Jagpreet Grewal1, Neeta Tripathi2, Ben Bortner1
1Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
概括
心友3风险评分 (HM3RS) 准确预测了接受心友3左心室辅助装置 (LVAD) 的患者的死亡率. 它的预测价值在不符合试验标准的患者下降.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 临床试验 临床试验
背景情况:
- 心友3风险评分 (HM3RS) 是使用MOMENTUM 3试验数据开发的.
- 它预测了Heartmate 3左心室辅助装置 (LVAD) 植入之前的患者的1年和2年的死亡风险.
研究的目的:
- 为了评估HM3RS在现实世界,未经选择的患者群体中的性能.
- 评估那些不符合MOMENTUM 3试验的纳入标准的患者的HM3RS准确性.
主要方法:
- 在2017年至2021年期间接受HM3 LVAD植入的521名患者的回顾性分析.
- 患者被评估是否有资格参加MOMENTUM 3试验.
- 使用时间依赖的接收器运行特征曲线分析来评估HM3RS风险歧视1年死亡率.
主要成果:
- 整体1年和2年生存率分别为85%和81%.
- 在满足和不满足MOMENTUM 3试验资格标准的患者之间,生存率没有显著差异.
- 在整个队列中,HM3RS显示出足够的风险歧视 (AUC 0.63),在符合试验标准的患者中表现更好 (AUC 0.69),而不是在不符合试验标准的患者中 (AUC 0.58).
结论:
- 在接受HM3 LVAD的患者中,无论他们是否符合试验资格,都观察到优异的1年和2年生存率.
- HM3RS在与MOMENTUM 3试验中的患者相似的患者中显示出足够的预测价值.
- 在那些不符合原始试验的纳入标准的患者中,HM3RS的预测准确性下降.
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