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使用两个自主开发的InDel面板来探索族群中的法医特征和祖先组件

Xi Yuan¹, Xi Wang¹, Qiong Lan²

¹Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.

|December 7, 2023

概括

两个新的DNA面板有助于法医科学. 多InDel面板在个人识别和父权测试方面表现出色,而AIM-InDel面板准确地推断出中国族群的生物地理祖先.

科学领域:

法医遗传学法医遗传学
人口遗传学人口遗传学
人类识别人类识别

背景情况:

退化DNA分析在法医调查中提出了重大挑战.
新型遗传标记物和面板对于提高法医案例工作效率至关重要.

研究的目的:

评估两个新开发的DNA面板的有效性,即一个祖先信息标记插入/删除 (AIM-InDel) 面板和一个多插入/删除 (Multi-InDel) 面板,用于中国族人口中的法医应用.
评估这些面板对于个人识别,亲属关系分析和生物地理祖先推断的实用性.

主要方法:

开发和应用AIM-InDel面板用于祖先推断.
开发和应用多InDel面板用于个人和亲属身份识别.
法医参数计算和模拟中国族群中的家庭关系.
种群结构分析和基因距离与参考种群的比较.

主要成果:

多InDel小组在族群的个人识别,父亲测试和亲属识别方面表现出很高的有效性,完全兄弟姐妹的真实阳性率为96.553%.
该AIM-InDel小组证明有效的生物地理祖先推断,区分东亚,非洲和欧洲人口.
在26个参考种群中,惠族人群与北京汉族人群的基因距离是最接近的.

结论:

开发的Multi-InDel和AIM-InDel面板是惠族人群中法医应用的宝贵工具.
这些小组显著提高了在法医案例工作中的个人识别,亲属测试和生物地理祖先推断的能力.

关键词:

在 AIM-InDel 中.法医遗传学法医遗传学族群族群族群多个内部的Del.人口遗传学人口遗传学

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