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在血液学和瘤学会议上使用主观最小化语言:系统性审查
Abdel-Azez Abusamak1, Mohammad Abusamak2, Mohammed Al-Abbadi3
1Department of Internal Medicine, Rutgers Health, RWJ Trinitas Regional Medical Center, Elizabeth, NJ, USA.
瘤学摘要中的主观最小化语言可能会掩盖治疗安全性. 更清晰地报告不良事件对于以患者为中心的护理和准确的试验解释至关重要.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 医学伦理 医学伦理
背景情况:
- 瘤学摘要中的主观最小化语言 (例如",安全"",耐受") 可以阻碍以患者为中心的护理.
- 这些术语缺乏标准化的解释,使跨试验比较复杂化,并可能淡化治疗风险.
研究的目的:
- 评估主观最小化语言在主要瘤学会议摘要中的流行程度和影响.
- 评估使用这种语言的摘要中关于不良事件 (AE) 的报道.
主要方法:
- 在2019年1月1日至2021年12月31日期间发表的ASCO,ASH和ESMO摘要的系统搜索.
- 在摘要中包含潜在的人类队列研究或临床试验,使用特定的安全术语,如"安全"或"耐受良好".
主要成果:
- 15.2%的审查摘要 (共2797篇) 使用主观最小化语言.
- 经常使用"安全" (69.2%) 和"耐受良好" (53.2%) 等术语被观察到.
- 使用这种语言的摘要经常报告AE,包括III级/IV级 (78%) 和V级 (8.8%),其中11.4%因AE而停止治疗.
结论:
- 在瘤学摘要中普遍使用主观最小化语言可能会掩盖研究结果和新治疗方法的安全性.
- 准确,标准化的报告对于准确解释干预对患者安全和福祉的影响至关重要.
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