暴露于内分泌干扰塑化剂和儿童和青少年的肺功能:系统性审查和元分析
Thomas Boissiere-O'Neill1, Wen R Lee2, Tamara L Blake2
1Child Health Research Centre, The University of Queensland, Centre for Children's Health Research, South Brisbane, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Environmental research
|December 7, 2023
概括
暴露于像酸盐这样的内分泌干扰塑化剂 (EDP) 可能会轻微降低儿童的肺功能. 关联在男性中更明显,但需要进一步的研究来证实这些发现.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 毒理学 毒理学 毒理学
背景情况:
- 暴露于内分泌干扰塑化剂 (EDP),包括酸盐和双,已与儿科患者的肺功能下降有关,尽管现有证据不一致.
- 本系统性审查和元分析通过评估有关EDP暴露与儿童和青少年肺功能之间的关联的流行病学证据来解决这些相互矛盾的结果.
结论:
- 分析表明,儿童和青少年肺功能小幅下降与更高的甲酸盐暴露有关.
- 虽然特定的酸盐对FEV1和FVC等肺功能参数具有边际影响,但由于潜在的偏差,整体关联仍然不确定.
- 需要进一步的研究,特别是在较年轻的年龄组,以阐明内分泌干扰塑化剂暴露与儿科肺功能之间的关系.
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