在外周动脉疾病中,氧气供应受损与认知衰退之间的联系
Johannes Burtscher1, Grégoire P Millet1, Marco Fresa2
1Institute of Sport Sciences, University of Lausanne, 1015 Lausanne, Switzerland; Department of Biomedical Sciences, University of Lausanne, 1005 Lausanne, Switzerland.
Progress in cardiovascular diseases
|December 7, 2023
概括
周围动脉疾病 (PAD) 会增加脑损伤的风险. 运动和氧气水平调节显示出减轻PAD患者认知衰退的潜力.
科学领域:
- 心血管科学 心血管科学
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 周围动脉疾病 (PAD) 影响大动脉,但也会增加脑损伤,认知衰退和痴呆的风险.
- 了解PAD和大脑健康之间的联系对于患者的治疗结果至关重要.
研究的目的:
- 审查最近关于将PAD与大脑后果联系起来的机制的文献.
- 在PAD患者中确定认知衰退和脑损伤的新疗法策略.
主要方法:
- 对研究PAD和大脑健康的文献综述.
- 对潜在机制和治疗干预措施的分析.
主要成果:
- 运动改善了全身血流和氧气供应,有利于PAD和认知衰退.
- 调节启发氧度 (低氧调节) 是一种新的治疗途径.
- 低氧适应的遗传和药理方法显示出临床前的希望,但缺乏临床验证.
结论:
- 虽然基因/药物调节具有挑战性,但治疗氧气水平的变化为PAD认知衰退提供了有前途的未来干预措施.
- 针对全身血流和氧化是缓解PAD相关的大脑风险的关键.
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