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在动物的lamus中自发的慢波中传播人口活动模式

Csaba Horváth¹, István Ulbert², Richárd Fiáth²

¹Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Budapest, Hungary; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary.

|December 7, 2023

概括

在麻醉和睡眠中,在缓慢波 (SWs) 期间,在丘脑中发生神经元活动的传播. 这种thalamic传播,特别是沿着dorsoventral轴,表明一个内在的thalamocortical网络属性.

科学领域:

神经科学是一个神经科学.
电力生理学电力生理学
系统神经科学系统神经科学

背景情况:

缓慢波 (SWs) 是麻醉和睡眠期间在甲状腺皮质系统中发生的关键电生理事件.
虽然皮层SWs显示复杂的时空动态,但SWs期间的thalamic传播仍然不太了解.

研究的目的:

为了调查质神经元活动是否表现出与SWs期间在新皮质中观察到的类似的传播特性.
描述在同步大脑状态期间的thalamic人口活动的时空动态和方向性.

主要方法:

高密度探测器记录在胺/西拉麻醉的老鼠和小鼠中.
同时记录新皮层和thalamic活动.
慢性记录在自然睡眠的老鼠在慢波睡眠期间.

主要成果:

在上位状态期间传播的自发性乳头活动,主要在背部乳头核 (Po,LP,LD) 中.
活动主要沿着dorsoventral轴传播,在超过一半的上部状态中观察到腹部到背部的传播.
在麻醉下发现皮质和胸膜传播模式之间存在微弱但明显的相互关系.
在自然睡眠期间,也检测到在丘脑中传播活动,但与麻醉相比,发生率较低,速度更快.

结论:

繁殖人口活动是thalamocortical网络在睡眠和麻醉等同步状态的内在特征.
新皮质可以在麻醉下对体传播模式施加部分控制.
这些发现有助于我们更好地了解全球大脑状态期间的甲状腺皮层网络动态.

关键词:

多个单位的活动多个单位的活动.宣传活动活动的传播.缓慢的振荡缓慢的振荡.缓慢的波浪缓慢的波浪泰拉姆斯 (thalamus) 是一个神经元.在州北部.

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