早期和晚期发病的肌性侧面硬化症患者的皮质灰质差异变化
Yuan Ai1,2, Fei Li1,2, Yanbing Hou3
1Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041, China.
Cerebral cortex (New York, N.Y. : 1991)
|December 7, 2023
概括
肌缩侧面硬化症 (ALS) 亚型显示出明显的脑部变化. 早发性ALS (EO-ALS) 患者的灰质体积减少,而晚发性ALS (LO-ALS) 患者的体积增加,这表明不同的病理机制.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 发病时的年龄是amyotrophic lateral sclerosis (ALS) 分类的一个关键因素.
- 独特的神经病理机制可能是早期发病的ALS (EO-ALS) 和晚期发病的ALS (LO-ALS) 的基础.
- 了解这些差异对于有针对性的治疗策略至关重要.
研究的目的:
- 为了研究EO-ALS和LO-ALS患者之间灰质体积 (GMV) 的神经病理差异.
- 为了确定受疾病发病年龄影响的特定大脑区域.
- 探索ALS亚型中GMV和疾病严重程度之间的关系.
主要方法:
- 使用基于voxel的形态测量 (VBM) 分析来比较GMV.
- 90名ALS患者被分为EO-ALS和LO-ALS组.
- 一百二十八个健康对照被匹配为年轻对照 (YC) 和老对照 (OC).
主要成果:
- 在多个大脑区域观察到显著的发病年龄-通过诊断的相互作用,包括骨,前中心,后中心,尾和轨道前皮层.
- 与YCs相比,EO-ALS患者在受影响地区表现出GMV降低.
- 与OCs相比,LO-ALS患者在大多数受影响地区的GMV增加,并且在考虑到衰老影响后,与EO-ALS患者相比,GMV增加.
- 在左侧后中枢环中的GMV与两组ALS的疾病严重程度相关.
结论:
- 病理性ALS机制可能因发病时的年龄不同而有所不同.
- 这些发现突显了ALS亚型中的临床和生物异质性.
- 这项研究为EO-ALS和LO-ALS的独特神经生物学基础提供了宝贵的见解.
关键词:
发病时的年龄在开始时.骨髓缩侧面硬化症 (ALS) 是一种感觉运动皮层 (sensorimotor cortex) 是一个感觉运动皮层.结构性大脑磁力共振成像 (MRI).基于voxel的形态测量方法更多相关视频
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