功能连接介导的大脑小血管疾病相关的认知障碍和抑郁症的特征模式
Jingxian Xu1, Haifeng Chen2,3,4,5, Zheqi Hu1
1Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu 210008, China.
Cerebral cortex (New York, N.Y. : 1991)
|December 7, 2023
概括
患有认知障碍和抑郁症的脑小血管疾病患者表现出不同的功能网络模式. 网络连接的变化调解了白质超强度,认知衰退和抑郁症状之间的关系.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 老年学是一门学科.
背景情况:
- 大脑小血管疾病 (CSVD) 在老年人中很普遍,通常与认知障碍和抑郁症同时发生.
- 在CSVD患者的认知功能障碍和抑郁症状之间的复杂关系仍然不完全理解.
研究的目的:
- 为了研究CSVD患者的功能网络连接模式,同时存在轻度认知障碍和抑郁症.
- 阐明特定功能网络在白质超强度,认知障碍和抑郁症之间的关联中扮演的调解角色.
主要方法:
- 使用静态和动态功能网络连接 (FNC) 分析.
- 在CSVD患者中检查了功能网络模式,其中包括轻度认知障碍和抑郁症 (CSVD-MCI-D).
- 评估了网络连接对白质超强度相关结果的调解效应.
主要成果:
- 在CSVD-MCI-D个体中确定了特定的静态和动态FNC模式.
- 在CSVD患有抑郁症的患者中观察到显著不稳定的动态FNC状态.
- 证明传感运动和腹部注意力网络连接性介导了白质超强度对认知障碍和抑郁症的影响.
- 发现认知功能负面调节白质过强度相关的抑郁症.
结论:
- 特定的功能网络变化标志着CSVD患者同时出现认知障碍和抑郁症.
- 动态FNC不稳定性是CSVD相关抑郁症的一个关键特征.
- 在CSVD中,互联网连接在调解血管大脑变化,认知衰退和情绪障碍之间的联系方面发挥着至关重要的作用.
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