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Updated: Jul 9, 2025

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集群CTCF边界内的面向外的位点是TAD内染色体相互作用和基因调节的关键

Xiao Ge1,2, Haiyan Huang1,2, Keqi Han1,2

  • 1Center for Comparative Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, State Key Laboratory of Systems Medicine for Cancer, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.

Nature communications
|December 7, 2023
PubMed
概括

令人惊的是,TAD边界的面向外的CTCF结合点对于基因调节至关重要. 删除这些位点会破坏增强剂-促进剂相互作用,影响基因激活和3D基因组组织.

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