杏仁体对于识别记忆的熟悉方面是不必要的
Benjamin M Basile1,2, Vincent D Costa3,4, Jamie L Schafroth3,5
1Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA. basileb@dickinson.edu.
Nature communications
|December 7, 2023
概括
杏仁体对于熟悉物品识别记忆并不重要,这与之前的动物研究相反. 这项针对 rhesus 子的研究挑战了杏仁体的功能.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 灵长类动物的行为
背景情况:
- 双流程理论提出回忆和熟悉度介于物品识别.
- 之前的动物研究表明,杏仁核在基于熟悉性的识别中起着关键作用.
研究的目的:
- 调查杏仁体在非人类灵长类动物中基于熟悉性的物品识别中的作用.
- 测试关于杏仁体损伤会损害 rhesus 的熟悉性假设.
主要方法:
- 在雄性 rhesus 子中诱导了选择性双边激发性杏仁体病变.
- 四个视觉记忆测试评估了熟悉度:错误报警,诱惑错误报警,ROC曲线和同一天/跨日歧视.
- 一个三臂强盗博任务通过奖励处理评估验证了损伤的有效性.
主要成果:
- 在四个熟悉性测试中的三项测试显示,杏仁体损伤后没有显著的损伤.
- 第四个测试的结果归因于奖励处理缺陷,而不是熟悉度受损.
- 桃体受伤的子在博任务中表现出预期的缺陷,证实了病变的有效性.
结论:
- 杏仁核对 rhesus 子的物品识别记忆中的熟悉性并不至关重要.
- 这些发现与之前的动物研究相矛盾,表明桃体在记忆中具有特定物种的作用.
- 杏仁体在记忆中的功能可能与奖励处理比熟悉性检测更密切相关.
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