靠近红外光触发的前药物光解通过一阶段的能量转移
Kaiqi Long1,2,3, Wen Lv3,4, Zihan Wang1,2,3
1State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong, China.
Nature communications
|December 7, 2023
概括
这项研究引入了一种新的近红外 (NIR) 光触发前药物光解的新方法,使用光敏剂和能量转移. 这种方法可以为先进的光激活癌症治疗提供精确的药物释放.
科学领域:
- 摄影化学的使用.
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 产药光解为向治疗提供了对药物释放的时间空间控制.
- 近红外线 (NIR) 光是理想的光激活疗法由于深层组织透和低光毒性.
- 目前的可光分解组通常缺乏由NIR光直接激活.
研究的目的:
- 通过一种类似上转换的能量转移过程,开发一种NIR光触发前药物光解的方法.
- 为了使绿光响应药物释放使用由NIR光激活的单光子过程.
- 通过微粒纳米系统来证明这种策略在癌症治疗中的潜力.
主要方法:
- 使用光敏剂 (PS) 进行单-三次 (S-T) 吸收和三次-三次能量转移.
- 使用二甲基 (BODIPY) 基预制药用于光解.
- 开发了一个状纳米系统,封装了PS和前药物,用于体外研究.
主要成果:
- 实现了高产率 (高达87%) 的基于BODIPY的前期药物的NIR光触发光解.
- 在低辐射的NIR光下 (100mW/cm2,5分钟) 显示对绿光反应的药物释放.
- 成功地将PS和前药物封装在微粒纳米系统中,用于Normoxia水性环境中应用.
结论:
- 开发的策略可以通过单步能量转移过程实现高效的NIR光触发前药物光解.
- 这种方法促进了光激活疗法,具有精确的时空释放药物.
- 这些发现推动了光分离性前药物和光响应性药物递送系统的开发,用于癌症治疗.
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