环境决定因素和人口对全球城市微生物群的影响,抗菌素耐药性和病原性
Yang Chen1, Xi Fu2, Zheyuan Ou1
1Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, P. R. China.
城市空气质量和绿色显著影响微生物多样性. 管理这些因素,以及社会经济方面的考虑,比如在GDP较低的地区减少抗生素的使用,是控制城市微生物群和抗菌素耐药性的关键.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 城市生态城市生态学
背景情况:
- 城市微生物对人类健康和疾病至关重要.
- 在全球范围内,MetaSUB联盟已经在60个城市中对城市微生物社区进行了分析.
- 环境和人口因素对城市微生物群的影响需要进一步阐明.
研究的目的:
- 研究35个环境和人口特征对全球城市微生物群多样性和组成的影响.
- 确定塑造城市微生物群落和抗菌素耐药性的关键因素.
- 为管理城市微生物生态系统提供见解.
主要方法:
- 利用PERMANOVA和回归模型来分析环境/人口数据和微生物组资料之间的关系.
- 在60个全球城市收集了35个不同的环境和人口变量.
- 采用了法典对应分析 (CCA) 来将微生物物种与环境变化联系起来.
主要成果:
- PM10度与微生物α-多样性有正相关,而人均GDP显示出负相关.
- 七个环境因素,包括气候,植被和空气污染,显著塑造了β-多样性,解释了20.3%的微生物变异.
- 抗微生物药物耐药性基因与人均GDP负相关,与太阳辐射正相关;病原体患病率与人口和温度有关.
结论:
- 空气质量 (PM10,PM2.5) 和城市绿色是城市微生物多样性和组成的主要调节因素.
- 社会经济因素,特别是人均国内生产总值,影响了微生物多样性和抗菌素耐药性的流行.
- 有针对性的干预措施,包括空气质量管理和减少GDP较低地区的抗生素使用,对于更健康的城市环境至关重要.
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