牙周炎的唾液微生物群通过肠道微生物群加剧结肠炎引起的焦虑行为
Jun Qian1, Jiangyue Lu1, Shuyu Cheng1
1Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
NPJ biofilms and microbiomes
|December 7, 2023
概括
牙周炎唾液微生物群 (PSM) 通过改变肠道微生物群和histidine代谢来加剧小鼠的焦虑类行为. 这突显了口腔健康与神经疾病中的肠-大脑轴之间的关键联系.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴描述了肠和中枢神经系统之间的双向通信.
- 口腔细菌,包括唾液中的细菌,可以影响肠道微生物群和大脑健康.
- 牙周炎是一种口腔疾病,会改变唾液微生物群的组成,但其对肠-大脑轴的影响尚不清楚.
研究的目的:
- 通过肠-大脑轴研究牙周炎唾液微生物群 (PSM) 在焦虑类行为中的作用和机制.
- 为了确定PSM是否会在小鼠大肠炎模型中加剧焦虑.
主要方法:
- 在小鼠使用硫酸盐 (DSS) 诱导类似焦虑的行为.
- 对比健康的唾液微生物群与PSM对行为,神经元完整性和微质激活的影响.
- 评估肠道微生物群的作用,使用抗生素治疗和便微生物群移植.
- 肠道和大脑样本的代谢分析,以确定受影响的代谢途径.
- 调查希斯蒂丁代谢变化的研究.
主要成果:
- 在DSS治疗小鼠中,PSM显著恶化了类似焦虑的行为.
- 在DSS小鼠的大脑中,PSM减少了正常神经元,并增加了激活的微质细胞.
- PSM的影响取决于肠道微生物群,需要进行DSS治疗.
- 在肠道和大脑中,PSM改变了histidine的代谢.
- 用histidine代谢物的补充模仿了PSM的焦虑加剧作用.
结论:
- 牙周炎的唾液微生物群可以加剧结肠炎引起的焦虑行为.
- 该机制涉及肠道微生物群和histidine代谢的改变.
- 口腔健康在调节肠-大脑轴和神经健康方面发挥着至关重要的作用.
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