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在神经性厌食症和强烈的体力活动中,垂体腺体的结构功能关系
Manel Merabet1, Natacha Germain2,3,4, Jérôme Redouté5
1TAPE Research Unit, EA 7423, Jean Monnet University, Saint Etienne, France.
Brain structure & function
|December 7, 2023
概括
神经性厌食症 (AN) 和运动员的营养不良会减少前垂体腺体体积,体重增加后恢复. 这种前垂体腺体体积的减少与低体重和荷尔蒙变化有关.
科学领域:
- 神经内分泌学神经内分泌学
- 放射学 放射学是一门学科.
- 人体生理学 人体生理学
背景情况:
- 神经性厌食症 (AN) 和运动训练涉及显著的生理压力,包括由于营养不良导致的荷尔蒙乱.
- 以前的垂体腺 (PG) 评估没有区分前 (AP) 和后 (PP) 叶.
- 在这些条件下了解PG结构-功能关系对于评估长期健康影响至关重要.
研究的目的:
- 为了评估前後垂体腺的结构功能关系,在妇女与AN和运动员.
- 在重量恢复的AN患者 (AN_Rec) 中研究垂体变化的潜在可逆性.
- 为了将下垂体体积与人体,荷尔蒙和心理参数相关联.
主要方法:
- 从T1加权MRI扫描中手动划分前部 (AP) 和后部 (PP) 垂体腺体体积.
- 包括17名患有AN的女性,15名AN_Rec,18名女运动员和25名女性对照.
- 探索和对比人类,荷尔蒙 (包括LH,GH) 和心理测量数据与PG卷.
主要成果:
- 与对照人群相比,AN,AN_Rec和运动员的前垂体腺体体积 (APV) 显著降低.
- 与AN_Rec相比,APV在AN中较小.
- 后垂体腺体 (PP) 体积在各组之间没有差异. APV与总体AN和黄素化激素 (LH) 的体重呈正相关性. 平均生长激素 (GH) 显示与全球PG和APV的反向相关性.
结论:
- 绝对 (AN) 和相对 (运动员) 营养不良导致前垂体腺体体积的减少,随着体重增加而可逆.
- 观察到的APV降低与低体重和下丘脑-垂体轴的改变有关.
- APV和GH之间的反相关性表明前垂体储存能力可能受到损害,并在低IGF-1的反应中增加反应性.
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