银纳米颗粒由益生菌合成,在耐药细菌中发挥抗菌作用
Eman Khalifa1, Mohamed Abdel Rafea2, Nazir Mustapha2
1Department of Microbiology, Faculty of Veterinary Medicine, Matrouh University, Matrouh, 51511, Egypt. khalifa.eman@alexu.edu.eg.
AMB Express
|December 7, 2023
概括
使用Lactobacillus acidophilus生物合成的银纳米颗粒显示出强大的抗菌活性对抗多药耐药细菌. 这种环保的方法为对抗危险感染提供了传统抗生素的有希望的替代方案.
科学领域:
- 纳米技术 纳米技术
- 微生物学 微生物学
- 生物化学 生化学
背景情况:
- 危险细菌的抗生素耐药性构成了全球健康的重大威胁.
- 迫切需要新的抗微生物策略来对抗多药耐药 (MDR) 病原体.
研究的目的:
- 为了研究由Lactobacillus acidophilus生物合成的银纳米粒子 (AgNPs) 作为潜在的抗菌剂.
- 评估这些AgNP对MDR细菌的抗菌疗效和细胞毒性.
主要方法:
- 使用紫外线视觉光谱测量,FTIR,XRD和SEM对生物合成的AgNP进行表征.
- 在老鼠中的细胞毒性评估和生理功能分析.
- 抗菌活性测试针对普洛特菌,大肠杆菌,金黄色葡萄球菌和肺炎菌.
- 使用滴滴数字PCR和DNA测序进行基因表达分析.
主要成果:
- AgNP范围在33-90nm之间,并通过各种分析技术得到证实.
- 在老鼠中观察到最小的毒性,一些生理参数显示出显著的差异.
- 对所有测试的MDR细菌菌株显示出高抗菌活性.
- 在接受治疗的细菌中观察到基因调节差异 (上下调节),包括mecA和β-lactam基因.
结论:
- 来自乳杆菌酸性的银纳米颗粒是有效的抗微生物对抗MDR细菌.
- 这些生物合成的AgNP代表了一种环保和有前途的治疗选择.
- 对基因调节机制的进一步研究为抗菌作用提供了洞察力.
关键词:
在AgNPS中使用AgNPS.抗菌剂 抗菌剂 抗菌剂细胞毒性 细胞毒性牛乳杆菌 (Lactobacillus) 是一种细菌.在MDR中使用MDR.纳米银的使用方法益生菌是一种益生菌.测序测序是指测序的时间.更多相关视频
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