布鲁萨托尔通过抑制Nrf2在差异化甲状腺癌中减弱了KRAS诱导的扩散和入侵

Z Gong1,2, L Xue1, A C Vlantis1

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.

概括

核因子红色素2相关因子2 (Nrf2) 在差异化甲状腺癌 (DTC) 中由KRAS上调,促进脱差. 用布鲁萨托尔抑制Nrf2抑制了KRAS驱动的瘤生长,这表明Nrf2是治疗点.

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