基于SEER数据库的竞争性风险分析来评估患有微侵袭性皮肤状细胞癌的患者的预后
Suzheng Zheng1, Shuping Xie2, Hai Yu1
1Department of Dermatology, The First Affiliated Hospital of Jinan University and Jinan University Institute of Dermatology, Guangzhou, China.
BMC medical research methodology
|December 7, 2023
概括
细灰模型确定了年龄,瘤大小和收入作为微侵袭性皮肤状细胞癌 (micSCC) 死亡率的关键预测因素. 这种方法为micSCC.患者提供了更准确的风险评估.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 传统的考克斯回归可能会对微侵袭性皮肤状细胞癌 (micSCC) 的死亡风险产生偏差结果.
- 特定原因死亡率数据对于在micSCC患者管理中做出明智的临床决策至关重要.
研究的目的:
- 应用细灰竞争风险模型来确定micSCC相关死亡率的独立风险因素.
- 为了提高micSCC患者的预后评估的准确性.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库 (2000-2015) 获取患者数据.
- 使用精细灰色和考克斯回归模型进行多变量分析.
- 使用格雷测试和累积发病率函数进行了单变量分析.
主要成果:
- 在1259名micSCC患者中,38人死于micSCC,100人死于其他原因.
- 无变量分析显示死亡风险与年龄,性别,婚姻状况,AJCC阶段,辐射,总结阶段,化疗,手术和瘤大小之间的关联.
- 多变量分析确定了年龄,瘤大小和收入作为micSCC死亡率的独立预测因素.
结论:
- 细灰模型为分析micSCC死亡率提供了一个强大的框架.
- 年龄,瘤大小和收入是micSCC死亡率的重要独立风险因素.
- 研究结果支持改善微SCC风险分层和个性化治疗策略.
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