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血栓形成和衰老:纤维素凝块特性和氧化应激
Małgorzata Konieczyńska1,2, Joanna Natorska1,2, Anetta Undas1,2
1Department of Thromboembolic Disorders, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
Antioxidants & redox signaling
|December 8, 2023
概括
老龄化增加了由于氧化应激改变纤维素结构和功能的血栓形成风险. 本综述探讨了这些与年龄相关的原血栓机制及其对血栓的影响.
科学领域:
- 生物医学科学 生物医学科学
- 老年学是指老年学的学科.
- 血液学 血液学 血液学
背景情况:
- 衰老是一个复杂的过程,与疾病风险增加有关,尤其是血栓形成.
- 氧化应激及其对蛋白质功能的影响,特别是纤维素素,是与年龄相关的前血栓状况的关键因素.
研究的目的:
- 审查血栓栓塞症中与年龄相关的前血栓机制.
- 专注于氧化应激如何改变纤维素结构和功能.
- 探索对动脉血症和静脉血栓症的影响.
主要方法:
- 关于衰老,氧化应激和血栓形成的现有文献的综述.
- 分析纤维素结构和功能的作用.
- 对参与凝血的蛋白质的翻译后修饰的检查.
主要成果:
- 衰老会增加氧化应激,导致氧化剂/抗氧化剂平衡受损,以及像纤维蛋白质这样的氧化蛋白质.
- 与年龄相关的前血栓变化包括血小板激活,内皮功能障碍和凝血因子的变化.
- 更紧的纤维素凝块与纤维素分解受损,有助于血栓形成,受蛋白质碳化作用的影响.
结论:
- 氧化应激显著影响纤维素凝块的结构和功能,导致与年龄相关的血栓形成.
- 纤维素凝块特性影响抗凝剂和抗血小板治疗的疗效和安全性.
- 需要进一步的研究来澄清氧化修饰在健康衰老中的作用,并开发有针对性的疗法.
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