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外体细胞在结肠直肠癌中的功能,潜在机制和临床潜力

Jinhong Han¹, Shuai Ma², Yao Zhao²

¹Department of Human Anatomy and Histology, School of Basic Medical Sciences, Xinxiang Medical University, 453000 Xinxiang, Henan, China.

Frontiers in bioscience (Landmark edition)

|December 8, 2023

概括

外体,体液中的微小囊泡,参与结直肠癌 (CRC) 的发展. 本综述探讨了它们作为CRC的诊断和预后标志物的作用和潜力.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
生物化学生物化学

背景情况:

结肠直肠癌 (CRC) 是一个主要的全球健康问题.
外体是细胞外囊泡中介细胞间通信.
外基因组在CRC病原和临床效用中的作用需要进行系统的评估.

研究的目的:

阐明外体在结直肠癌发生和进展中的参与.
分析CRC中瘤衍生的和非瘤衍生的外体的功能和机制.
评估外体细胞作为CRC的诊断和预后生物标志物的潜力.

主要方法:

文献综述和对外体和CRC现有研究的综合.
对调查外体生物发生,载荷和细胞间信号的研究进行分析.
对临床数据和实验证据关于基于外体的CRC检测和预后的审查.

主要成果:

外基因组通过各种分子机制促进CRC的发展.
瘤衍生和非瘤衍生外体都影响瘤微环境.
有证据支持使用外体作为CRC有前途的诊断和预后指标.

结论:

外基因组在结直肠癌的进展中发挥着多方面的作用.
了解外体的功能为CRC病变的产生提供了洞察力.
外体在CRC诊断,预后和治疗中具有显著的临床应用潜力.

关键词:

生物标志物生物标志物临床转变的临床转变结肠直肠癌是什么意思诊断诊断诊断诊断诊断诊断在外基因组中,外基因组是外基因组.

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