凯姆菲罗尔通过COX-2/PGE2途径改善与乳腺癌相关的抑郁症
Qing Zhu1, Yuanshan Han2, Ying He3
1Department of Pharmacy, Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 410013 Changsha, Hunan, China.
Frontiers in bioscience (Landmark edition)
|December 8, 2023
概括
凯姆菲罗尔通过减少炎症和改善神经递质水平,有效治疗与乳腺癌相关的抑郁症 (BCRD). 它通过抑制循环氧化酶-2 (COX-2) /前列腺素E2 (PGE2) 途径起作用,为BCRD提供了潜在的新疗法.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳腺癌相关抑郁症 (BCRD) 是乳腺癌 (BC) 的重要并发症,增加死亡率和复发率.
- 了解BCRD的机制对于开发有效的治疗方法至关重要.
研究的目的:
- 调查卡姆菲罗尔在BCRD病变发生中的作用.
- 阐明kaempferol抗BCRD作用的潜在分子机制.
主要方法:
- 使用4T1小鼠BC细胞和皮质 (Cort) 建立了一个BCRD小鼠模型.
- 使用行为测试,细胞测试,分子分析 (西方斑点,qPCR) 和生物化学测试来评估kaempferol的效果.
- 研究了循环氧酶-2 (COX-2) /前列腺素E2 (PGE2) 轴的作用,包括分子对接研究.
主要成果:
- 在小鼠中,kaempferol降低了4T1细胞活力,迁移和殖民地形成,并抑制了瘤生长和类似抑郁症的行为.
- 凯姆菲罗尔通过调节细胞因子水平 (IL-1β,IL-6,TGF-β1,IL-10) 和恢复神经递质平衡 (血清素,多巴胺,北上腺素) 来缓解神经炎症.
- 凯姆菲罗尔降低了COX-2和PGE2的表达,而COX-2的过度表达逆转了凯姆菲罗尔的保护作用.
结论:
- 凯费醇显示出显著的抗BCRD作用,可能通过抑制COX-2/PGE2通路.
- 这种抑制会影响神经炎症,神经递质失衡和神经发生,这表明凯姆菲罗尔是BCRD的有希望的治疗剂.
更多相关视频
相关概念视频
02:38Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
01:21G-protein Coupled Receptors
119.5K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
119.5K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:24Disorders of the Female Reproductive System
366
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
366
01:15Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K