相关实验视频

Updated: Jul 9, 2025

Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry
09:16

Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry

Published on: February 3, 2023

2.5K

在老化的RPE细胞中,PEDF可以防止线粒体功能衰减和ER压力,这些压力是由rotenone引起的

Ruixue Zhang1, Zhi Ji1, Zhuoya Quan1

  • 1Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Medical University, 710038 Xi'an, Shaanxi, China.

Frontiers in bioscience (Landmark edition)
|December 8, 2023
PubMed
概括

颜料上皮质衍生因子 (PEDF) 保护老化的视网膜颜料上皮质 (RPE) 细胞免受线粒体功能障碍和内分泌网膜 (ER) 应激,这些应激是由轮 (ROT) 引起的. 这一因素可以通过保持RPE细胞健康来预防与年龄相关的黄斑变性 (AMD).

关键词:
这是因为CaCaCa.在PEDF中,PEDF是PEDF.这就是ROSOS ROS.在RPE细胞中,RPE细胞线粒体中的线粒体.轮回一个,一个.

更多相关视频

Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy09:29

Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy

Published on: May 4, 2016

7.2K
Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry07:18

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024

1.1K

相关概念视频

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.1K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
13.8K
The Electron Transport Chain01:30

The Electron Transport Chain

The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
16.8K
The Unfolded Protein Response01:37

The Unfolded Protein Response

The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
4.6K