复杂的体外模型:药物开发和精准医学中的一个变革性模型
Luming Wang1,2, Danping Hu3, Jinming Xu1,2
1Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Clinical and translational science
|December 8, 2023
概括
复杂的体外模型 (CIVM) 为药物研究提供了3D的多细胞方法,克服了2D细胞培养的局限性. 这些先进的模型提高了药物发现和精准医学的生理相关性.
科学领域:
- 生物医学工程 生物医学工程
- 药物发现和开发 药物发现和开发
- 再生医学是一种再生医学.
背景情况:
- 在临床前研究中,传统的二维细胞培养与体内条件相比,存在显著的生理差异.
- 这些局限性阻碍了准确的药物疗效和毒性评估,影响了药物开发管道.
- 现有的体外模型往往无法复制器官和组织功能至关重要的复杂的细胞外微环境.
研究的目的:
- 审查和分析各种类型的复杂体外模型 (CIVMs).
- 检查CIVM的各种制造技术.
- 探索CIVM在药物发现,开发和精准医学中的应用.
主要方法:
- 复杂体外模型 (CIVM) 的综合文献综述.
- 对CIVM制造方法的分析,包括生物聚合物和组织衍生矩阵.
- 评估CIVM在临床前药物研究和精准医学中的应用.
主要成果:
- CIVM集成了多细胞和3D结构,以更好地模仿体内微环境.
- 这些模型增强了生理学相关性,提高了药物反应预测的准确性.
- CIVM为动物试验提供了一个有希望的替代方案,解决了伦理方面的担忧.
结论:
- 复杂的体外模型 (CIVM) 对临床前研究的传统二维培养来说是一个显著的进步.
- 它们回顾组织特异性特征的能力使得它们在药物发现,开发和精密医学方面具有宝贵的价值.
- 继续开发CIVM具有极大的潜力,可以加速治疗创新,减少对动物模型的依赖.
更多相关视频
13:34A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
Published on: April 6, 2016
10.2K
10:24Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
Published on: July 4, 2018
11.6K
相关概念视频
02:43Mouse Models of Cancer Study
5.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.6K
01:16In-vitro Mutagenesis
13.9K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
13.9K