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在选择性外科手术中,警报器和相关分子

Sabina Strohalmová^1,2, Kateřina Levová², Aleš Antonín Kuběna²

¹1st Department of Surgery - Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.

Folia biologica

|December 8, 2023

概括

手术显著改变了警示素和相关分子. 手术后的EN-RAGE,calprotectin,HMGB1和IL-6的水平增加,而sRAGE则下降,表明它们参与了手术反应.

科学领域:

生物化学生化学
免疫学免疫学免疫学
手术科学手术科学

背景情况:

众所周知,手术会诱导生理压力,影响各种分子信号通路.
警示剂和相关分子,如sRAGE,EN-RAGE,calprotectin,HMGB1和IL-6,在炎症和组织修复中起着至关重要的作用.

研究的目的:

为了研究选择性手术后特定的警示素和相关分子的血清度的动态变化.
为了比较那些接受选择性手术的患者和那些患有急性手术条件的患者的这些变化.

主要方法:

血清样本从58名接受或胆囊病手术的患者和21名健康对照组中收集.
使用ELISA在手术前和手术后测量了先进糖化最终产品 (sRAGE) 的可溶性受体,先进糖化最终产品结合蛋白 (EN-RAGE) 的细胞外新发现受体,calprotectin,高流动性组盒1 (HMGB1) 和介质素6 (IL-6) 的度.
七名急性手术患者 (尾炎,胆囊炎,监禁) 也被纳入用于比较.

主要成果:

在手术前,与对照组相比,患者显示calprotectin降低和sRAGE增加. EN-RAGE和HMGB1水平没有显著差异.
在术后,EN-RAGE,calprotectin,HMGB1和IL-6显著增加,而sRAGE与手术前水平相比显著下降.
在急性手术患者中,大多数生物标志物在手术前升高,sRAGE下降;手术进一步增加了IL-6,但对其他标志物的影响很小.

结论:

选择性手术显著影响测试生物标志物的度,除了sRAGE外,大多数都在术后增加.
观察到的变化表明,警示素和相关分子是外科手术启动的炎症和修复过程中的关键参与者.
在急性疾病中,这些生物标志物已经升高,表明了先前存在的炎症状态,而手术具有更有限的额外影响.

关键词:

愤怒的愤怒愤怒的愤怒这就是HMGB1的特点.在IL-6的研究中,IL-6被认为是IL-6的基因.这是一种calprotectin.选择性外科手术是一种选择性手术.伤害就是伤害.

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