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解封COVID-19疫苗接种后的不良事件和关联:深入研究疫苗不良事件报告系统数据
Yiming Li1, Sori K Lundin1,2, Jianfu Li1,3
1McWilliams School of Biomedical Informatics, the University of Texas Health Science Center at Houston, Houston, TX, USA.
Expert review of vaccines
|December 8, 2023
概括
使用VAERS数据分析了COVID-19疫苗不良事件 (AEs). 结果揭示了与年龄,性别和疫苗类型相关的特定副作用,为目标安全监测提供了信息.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 药物监督 药物监督 药物监督
背景情况:
- 快速部署COVID-19疫苗对于控制流行病至关重要.
- 监测与疫苗相关的不良事件 (AE) 对于公众的信任和安全至关重要.
研究的目的:
- 分析2020-2022年在疫苗不良事件报告系统 (VAERS) 中报告的COVID-19疫苗不良事件.
- 为了确定AE,人口因素 (年龄,性别) 和疫苗制造商之间的关联.
主要方法:
- 利用统计分析,包括零截断的波桑回归和物流回归.
- 检查了26个系统器官类别 (SOC) 和人口学变量之间的关联.
- 在不同的疫苗制造商 (Moderna,Pfizer,Janssen,Novavax) 中比较了AE概况.
主要成果:
- 在年龄,性别和特定的SOC之间发现了显著的关联.
- 女人患有与怀孕有关的疾病的几率更高;男性患有手术/医疗手术的几率更高.
- 老年人 (>65) 更容易患心脏疾病;年轻人 (18-65) 更容易患皮肤疾病.
- 与Janssen和Novavax相比,Moderna和Pfizer疫苗与较少的SOC症状有关.
- 估计每个人平均有4243个症状.
结论:
- 这项研究为COVID-19疫苗安全概况提供了关键的见解.
- 这些发现可以指导基于证据的疫苗接种策略,并加强药监工作.
- 精确的监测可以提高疫苗的安全性和公众的信心.
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