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血清miR-105-3p表达的动态变化和术后甲状腺癌的预后值评估

Jianping Zhou¹, Xiaolong Song², Yufang Li³

¹Department of Radioimmunity Center, Shaanxi Provincial People's Hospital, Xian, Shaanxi, 710068, China. zjpbon868@hotmail.com.

Cellular and molecular biology (Noisy-le-Grand, France)

|December 8, 2023

概括

血清miR-105-3p水平随着分化良好的甲状腺癌 (TC) 和淋巴结转移而增加. 手术后,水平下降,有助于预测预后,并可能作为生物标志物.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

甲状腺癌 (TC) 是一种常见的内分泌恶性瘤,起源于甲状腺上皮细胞.
确定可靠的生物标志物用于TC预后和术后监测至关重要.

研究的目的:

在TC手术后调查血清miR-105-3p表达的动态变化.
为了将血清miR-105-3p水平与TC的临床病理特征相关联.
评估血清miR-105-3p作为术后预后生物标志物的潜力.

主要方法:

从100名TC患者收集了血清样本.
对血清miR-105-3p水平的定量检测.
与临床病理学特征 (例如分化,淋巴结转移) 的相关性分析.
在手术后动态监测血清miR-105-3p水平.

主要成果:

血清miR-105-3p水平在患有有差异良好的TC和淋巴结转移的患者中升高.
与手术前水平相比,手术后4天观察到血清miR-105-3p显著下降.
血清miR-105-3p水平有效地区分了两年内预后良好和不良的患者.
该生物标志物显示出在TC手术后预测预后改善的潜力.

结论:

血清miR-105-3p水平与TC中的瘤分化和淋巴结转移密切相关.
手术后血清miR-105-3p的动态下降表明它在监测治疗反应中的有用性.
血清miR-105-3p对TC预后具有显著的诊断价值,可以作为一个有价值的术后生物标志物.

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