生命必需品8和慢性病之间的关联
Yuqing Ren1,2, Zongao Cai3, Chunguang Guo4
1Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China.
Journal of the American Heart Association
|December 8, 2023
概括
使用Life's Essential 8 (LE8) 改善心血管健康与较低的慢性病 (CKD) 患病率有关. 最佳的LE8得分,特别是血糖和血压,可以降低美国成年人患CKD的风险.
科学领域:
- 心血管健康和脏疾病研究研究
- 公共卫生和流行病学
背景情况:
- 慢性病 (CKD) 是一个重要的公共卫生问题,与心血管疾病密切相关.
- 现有研究强调了心血管健康和功能之间的联系.
- 最近对心血管健康指标的更新,Life's Essential 8 (LE8),为研究提供了一个新的框架.
研究的目的:
- 调查生活必需8 (LE8) 评分与美国成年人慢性病 (CKD) 患病率之间的关联.
- 为了确定是否遵守最佳心血管健康指南,以LE8测量,影响CKD风险.
- 探索LE8得分和CKD流行率之间的剂量反应关系.
主要方法:
- 利用了2007-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 包括20岁及以上的美国成年人,以人口为基础的大型样本.
- 采用多变量逻辑回归和受限立方支线模型来分析LE8和CKD之间的关联,并对混因素进行调整.
主要成果:
- 总共有24,960名参与者被分析,其中14.11%患有CKD.
- 较高的LE8得分表明与CKD患病率有显著的反向关联 (OR每10点增加:0.79;95%CI,0.76-0.83),表明非线性剂量反应关系.
- 特定的LE8成分,包括血糖和血压,独立地与降低CKD几率有关.
- 反向关联在中年,男性和结合的个体中更为明显.
结论:
- 生活必需品8 (LE8) 与慢性病 (CKD) 的较低患病率有显著且非线性相关.
- 通过遵守LE8促进最佳心血管健康可以作为减轻CKD公共卫生负担的战略.
- 针对血糖和血压等LE8关键成分对CKD预防工作至关重要.
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