化学定制的单个原子用于有针对性和光控制的杀菌活性
Zaoming Li1,2, Zhiqiang Zhao1, Shutong Chen1
1Department of Chemistry, Capital Normal University, No. 105 West Third Ring North Road, Beijing, 100048, China.
Advanced healthcare materials
|December 8, 2023
概括
化学修饰的单原子 (SA) 纳米颗粒显示出增强的向抗菌活性. 这些定制的SA纳米粒子有效地治疗伤口感染,并以最小的毒性促进愈合.
科学领域:
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 单原子 (SA) 纳米粒子具有有前途的光热特性,可以对抗细菌.
- 目前的局限性包括针对性和受控抗菌活性的有效性受到限制,阻碍了实际应用.
研究的目的:
- 通过化学修饰来克服SA纳米粒子抗菌功效的局限性.
- 使用定制的SA纳米颗粒来实现有针对性和光控制的抗菌作用.
主要方法:
- 使用谷氨 (GSH) 和酸 (MBA) 的酸盐的原子级改性.
- 对大肠杆菌细胞的向结合能力的评估.
- 在808nm激光照射下在老鼠模型中抑制伤口细菌的增殖和促进伤口愈合的抗菌疗效的评估.
主要成果:
- 修改后的SAS与氨酸修改后的SAS相比,对大肠杆菌细胞具有优越的向结合.
- 修改后的SA纳米颗粒有效抑制了伤口细菌的增殖.
- 在大鼠中促进伤口愈合,对主要器官没有显著的毒性.
结论:
- 化学工程对于定制SA纳米粒子抗菌特性至关重要.
- 定制的SA纳米颗粒为抗击细菌感染提供了一个有前途的战略.
- 这种方法推进了基于纳米粒子的治疗方法,用于伤口管理和感染控制.
相关概念视频
CRISPR and crRNAs
17.0K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.0K
Antibiotic Selection
54.1K
Overview
54.1K
Methods of Sterilization II: Chemical Methods
6.3K
In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
6.3K
Lytic Cycle of Bacteriophages
70.7K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
70.7K


