利用技术诊断阿尔茨海默病:系统性审查和元分析
Clemens Scott Kruse1, Michael E Mileski1, Reagan Wilkinson1
1School of Health Administration, Texas State University, San Marcos, TX 78666, USA.
Healthcare (Basel, Switzerland)
|December 8, 2023
概括
创新方法可以准确诊断阿尔茨海默病 (AD),改善患者的治疗结果. 然而,成功实施需要适当的提供者培训和意识到潜在的障碍,如成本和患者的存在.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 医学诊断 医学诊断 医学诊断
背景情况:
- 阿尔茨海默病 (AD) 影响全球5000万,预计到2050年将达到1.52亿.
- 大多数痴呆病例发生在65岁以上的人群中,但也有早期发病的形式.
- 早期发现AD对于及时治疗和改善患者结果至关重要.
研究的目的:
- 系统地审查和对AD诊断干预措施的研究进行元分析.
- 为AD诊断的临床实践指南的制定提供信息.
- 根据成本,效率,准确性和可接受性来评估干预措施.
主要方法:
- 系统的文献综述和过去10年发表的研究的元分析.
- 搜索了四个数据库:PubMed,CINAHL Ultimate,科学网和科学直播.
- 遵循克鲁塞协议,并使用PRISMA (2020) 准则进行报告.
主要成果:
- 在老年人中诊断AD的10种干预措施被确定,其中一些结合了MRI和PET等方法.
- 这些干预措施的准确性很高 (灵敏度为85.16%,特异性为88.53%),通常非侵入性,廉价和方便.
- 确定的障碍包括成本,培训要求,旅行费用和需要患者的身体存在.
结论:
- 新的诊断方法可以准确检测阿尔茨海默病.
- 使用这些干预措施,提供者培训和熟悉对于准确的AD诊断至关重要.
- 许多有效的AD诊断方法都是非侵入性的,对患者友好的,并且具有成本效益,尽管有些需要患者的存在.
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