纳米气泡介导氧化:阐明低氧和线粒体相关病理的潜在分子机制
Sergio M Viafara Garcia1,2,3,4,5, Muhammad Saad Khan6, Ziyad S Haidar1,2,3,7,8
1Programa de Doctorado en BioMedicina, School of Medicine, Universidad de los Andes, Santiago 8150513, Chile.
Nanomaterials (Basel, Switzerland)
|December 8, 2023
概括
氧纳米泡 (OnB) 为癌症和神经退行性疾病等缺氧相关疾病提供了一种新的治疗策略. 本综述探讨了OnB传递系统及其治疗代谢压力和多器官衰竭的机制.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 细胞生物学 细胞生物学
背景情况:
- 缺氧或低氧水平是癌症,COVID-19和神经退行性疾病等疾病的关键因素,通常导致多器官衰竭和死亡.
- 氧气对于细胞功能至关重要,如果氧气稀缺度低于10mmHg,就会引发线粒体功能障碍,并激活缺氧诱导因子 (HiFs).
研究的目的:
- 审查新兴的氧气纳米泡 (OnB) 技术作为提供氧气的多功能平台.
- 探索各种OnB输送策略及其纳米尺度机制,用于治疗缺氧相关的病理.
- 阐明OnB在线粒体代谢和慢性疾病的低氧反应中的作用.
主要方法:
- 关于氧气纳米气泡 (OnB) 氧气输送系统的现有文献的审查.
- 探索OnB策略,包括扩散,超声波,光动力学和pH响应方法.
- 分析与线粒体代谢 (TFAM,PGC1alpha) 和缺氧反应 (HiF-1alpha) 相关的OnB纳米级机制.
主要成果:
- 氧纳米泡 (OnB) 是一种有前途的方法,可以将氧气输送到缺氧组织中.
- OnB可以调节线粒体代谢和缺氧信号通路.
- 各种OnB系统在低氧相关疾病中显示出治疗应用的潜力.
结论:
- 氧气纳米泡提供了一种新的治疗途径,用于控制缺氧和代谢压力.
- 了解OnB机制对于开发癌症,神经退行性疾病和其他关键疾病的创新治疗方法至关重要.
- 对OnB平台的进一步研究可以在改善缺氧引起的病理方面取得重大进展.
相关概念视频
Hypoxia
1.1K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.1K
Mitochondrial Membranes
10.9K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
10.9K
Electron Transport Chain: Complex I and II
13.8K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
13.8K
Oxygen Transport in the Blood
2.7K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
2.7K
Physiological Control of Respiration
2.1K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
2.1K
Peroxisomes and Mitochondria
87.4K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
87.4K


