脉冲压变化的测量误差
Piet A H Wyffels1,2, Stefan De Hert3,4, Patrick F Wouters3,4
1Department of Basic and Applied Sciences, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium. piet.wyffels@uzgent.be.
Journal of clinical monitoring and computing
|December 8, 2023
概括
脉冲压变化 (PPV) 计算中的测量错误在流体管理中带来了不确定性. 这项研究量化了这些错误,表明所有方法都有不同程度的偏差和不准确性,影响了临床解释.
科学领域:
- 关键护理医学 关键护理医学
- 麻醉学 麻醉学
- 心血管生理学心血管生理学
背景情况:
- 动态预加载参数,如脉冲压变化 (PPV),指导外科手术期间的流体管理.
- 临床决策因可变报告的截止值和PPV的"灰色地带"而复杂化.
- 在PPV计算中的测量误差以前没有得到量化,但可能会导致不确定性.
研究的目的:
- 量化和比较与计算PPV的不同算法相关的测量误差.
- 评估抽样时间对PPV测量不确定性的影响.
- 为解释PPV值提供一个框架,考虑偏差和精度.
主要方法:
- 利用了VitalDatabase中肝移植患者的血液动力学数据.
- 应用了三种不同的算法来计算PPV在1分钟的观察期内,采样持续时间不同.
- 采用最佳线性无偏预测作为参考PPV和贝叶斯模型来确定偏差,精度和模拟不确定性.
主要成果:
- 所有测试的PPV计算方法都表现出测量误差,差异偏差范围从-0.04%到1.64%,比例偏差范围从0.92%到1.17%.
- 在所有方法中都检测到受样本采集期影响的异种粘性.
- 模拟显示了基准PPV值和变化的显著预测范围,即使测量PPV为12%或1%的变化.
结论:
- 所有计算PPV的方法都与固有的测量不确定性有关.
- 在不同的PPV计算方法中,偏差和精度的程度有所不同,并受到采样参数的影响.
- 计算量化偏差和精度对于准确解释PPV值和临床实践变化至关重要.
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