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Updated: Jul 9, 2025

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在骨髓瘤中,MMP-2通过抑制CHK/MATK瘤抑制剂来调节Src激活

Deanna V Maybee1, Christopher R Cromwell2, Basil P Hubbard2

  • 1Department of Pharmaceutical Sciences, SUNY Binghamton University School of Pharmacy and Pharmaceutical Sciences, Binghamton, New York, USA.

Cancer reports (Hoboken, N.J.)
|December 8, 2023
PubMed
概括

矩阵金属蛋白酶-2 (MMP-2) 抑制瘤抑制剂CHK/MATK,促进骨髓瘤细胞迁移. 向MMP-2可能会提高多克索鲁比辛治疗的有效性,并通过恢复CHK/MATK表达来降低化学抵抗.

关键词:
在Csk同类激酶 (CHK/MATK) 中.美国Src SrcSrc家族的激酶 (SFK) 的作用.德克索鲁比辛 (doxorubicin) 是一种药物.矩阵金属蛋白酶-2 (MMP-2) 是一种骨质肉瘤是骨质肉瘤的一种.

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