脑血管的CO2反应性和动态大脑自调节通过生命的第八个十年及其对认知能力下降的影响
Ralf Wj Weijs1, Madelijn H Oudegeest-Sander1,2, Maria Te Hopman1
1Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.
概括
脑血管二氧化碳反应能力随着年龄的增长略有下降,而动态脑自身调节 (dCA) 在老年人中略有增强. 这些脑血管变化与临床前认知能力下降有关,影响痴呆症管理策略.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 心血管生理学心血管生理学
背景情况:
- 衰老与大脑血流 (CBF) 的减少有关,特别是在临床前认知衰退的个体中.
- 大脑血管调节机制在衰老和早期认知衰退中的确切作用仍然不完全理解.
研究的目的:
- 研究与年龄相关的脑血管二氧化碳反应和动态脑自身调节 (dCA) 在生命第八十年的人群中的变化.
- 检查这些脑血管功能与早期认知衰退的开始之间的关系.
主要方法:
- 一项纵向研究涉及28名健康的老年人 (平均年龄为80.0岁),他们之前参加了基线评估 (平均年龄为70岁).
- 经过10.9年的随访期后,进行了重复的跨骨多普勒评估.
- 使用线性混合模型分析来评估大脑血管二氧化碳活性和dCA的变化.
主要成果:
- 随着年龄的增长,观察到大脑血管二氧化碳反应能力的小幅降低 (-0.37%/mmHg,P=0.041).
- 动态大脑自我调节 (dCA) 显示了适度的增强 (增益: -0.009 cm/s/mmHg,P=0.038;阶段: +8.9 度,P=0.004).
- 这些脑血管变化在患有主观记忆障碍的参与者中更为明显.
结论:
- 动态大脑自调节 (dCA) 在衰老过程中不会受到损害,尽管与年龄相关的大脑输液和脑血管反应率的降低.
- 脑血管健康在临床前认知衰退中起着重要作用.
- 这些发现对于开发痴呆症管理策略具有临床意义.
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