亚洲国家的HBV流行:系统性审查和元分析
Sam Hogan1, Andrew Page1, Sameer Dixit2
1Translational Health Research Institute, Western Sydney University, Syndey, NSW, Australia.
PloS one
|December 8, 2023
概括
南亚地区的乙型肝炎病毒 (HBV) 感染率高于全球平均水平. 流离失所的人口显示HBV的发病率增加,这表明疫苗接种计划实施的差异.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 构成了全球严重的健康负担,全球约有2.96亿人受到影响.
- 尽管存在疫苗接种计划,但特定人群持续呈现高HBV感染率.
研究的目的:
- 系统地审查和分析南亚国家B型肝炎病毒 (HBV) 的流行情况.
- 确定导致该地区内HBV流行率变化的因素.
主要方法:
- 对2010年以后在印度,巴基斯坦,孟加拉国,尼泊尔,斯里兰卡和不丹发表的HBV研究进行了系统的文献搜索.
- 从包含的研究中提取数据,分析聚合流行率,并接受子组分析,元回归和出版偏差评估.
主要成果:
- 在研究的国家中,HBV的整体综合流行率为3%.
- 聚合流行率因国家而异:印度 (3%),巴基斯坦 (6%),孟加拉国 (5%),尼泊尔 (1%).
- 观察到出版偏差和研究之间显著异质性的证据,大多数研究被评为公平或中等质量.
结论:
- 南亚亚洲次大陆的HBV患病率超过全球平均水平,但低于其他一些地区.
- 在流离失所人口较多的国家发现HBV的流行率更高,这表明疫苗计划的采用和实施的影响有所不同.
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