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乳腺癌史与降低甲状腺癌特定死亡率之间的关联
Shuhuang Lin1, Zhuo Wang1, Mingzhao Xing1
1Thyroid Research Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
The Journal of clinical endocrinology and metabolism
|December 8, 2023
概括
患有乳腺癌 (BC) 病史的患者在甲状腺癌 (TC) 的生存率有所改善. 这一发现表明BC史可能具有保护作用,有助于更准确的TC预后.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 甲状腺癌 (TC) 与乳腺癌 (BC) 之间的关联已经得到充分证实,但其临床意义需要进一步调查.
- 了解以前的BC诊断对TC预后的影响对于患者管理至关重要.
研究的目的:
- 评估乳腺癌 (BC) 史对甲状腺癌 (TC) 预后的影响.
主要方法:
- 使用监测,流行病学和最终结果 (SEER) 18数据库进行的比较队列研究.
- 分析包括5598名患有乳头甲状腺癌 (PTC) 和604名患有卵泡甲状腺癌 (FTC) 和BC史 (TC-BC) 的患者,与没有BC史 (TCnoBC) 的倾向性得分匹配的TC患者相比.
- 主要终点是TC特异性死亡率.
主要成果:
- 与TCnoBC患者相比,TC-BC患者在PTC和FTC亚型中表现出较低的远程转移率和TC特异性死亡率 (P < .05).
- 在TC-BC患者中,死亡风险比率显著降低:PTC为0.472,FTC为0.656 (P < .05).
- 在PTC中,当TC发生在BC (HR=0.397) 之前时,与BC发生在TC (HR=0.607) 之前相比,保护作用更强.
结论:
- 乳腺癌 (BC) 的病史表明对甲状腺癌 (TC) 特定存活率有显著的保护作用.
- 这些发现支持将BC史纳入甲状腺癌患者更精确的预后模型.
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