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R3-诺里亚甲硫酸盐:一种具有高超极化-129核磁共振对比度的分子

Yurii Shepelytskyi^1,2, Vira Grynko^2,3, Viktoriia Batarchuk^1,2

¹Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.

|December 8, 2023

概括

一种新型的树脂烯三元体,R3-Noria-MeSO3H,可以增强高极化129XeMRI对比度. 这种宏观循环提供了双对比机制,改善了核磁共振应用的分子成像潜力.

科学领域:

分子成像学分子成像学
磁共振成像技术磁共振成像技术
超分子化学超分子化学

背景情况:

超极化 (HP) -129 (129Xe) MRI是一种有前途的分子成像技术.
开发有效的对比剂对于推动HP 129XeMRI的发展至关重要.
以前的研究集中在用于子MRI应用的超分子子上.

研究的目的:

为了引入和评估一种新的宏循环,复二二烯三元甲硫酸盐 (R3-Noria-MeSO3H),用于HP 129XeMRI.
研究R3-Noria-MeSO3H在异MRI中提供的对比机制.
为了评估R3-Noria-MeSO3H在3.0 T的性能.

主要方法:

合成和表征复二烯三元基甲硫酸盐 (R3-诺里亚-MeSO3H).
在3.0 T获得HP 129XeMRI以评估对比度.
实现超极化化学交换和转移 (HyperCEST) 成像的实施.

主要成果:

在3.0T的HP 129XeMRI中,R3-Noria-MeSO3H显示出优异的负对比度.
宏观周期表现出两个明显的对比机制:增加旋转-旋转放松和HyperCEST.
我们成功地实现了R3-Noria-MeSO3H宏循环的HyperCEST成像.

结论:

R3-Noria-MeSO3H是一种独特的宏循环,有效用于异MRI.
双对比机制提高了其用于分子成像的实用性.
需要进一步研究R3-诺里亚甲硫酸盐的聚合行为和放松性.

关键词:

这就是HyperCEST.诺里亚·诺里亚 (Noria Noria) 是一个 R3-诺里亚甲硫酸盐-甲硫酸盐化学交换化学交换化学交换磁共振成像技术的使用磁共振光谱学磁共振光谱学 -129的使用情况

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