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Updated: Jul 9, 2025

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation
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使用机械静态药物动力学 (MSPK) 模型进行载体介导药物相互作用的定量预测

Satoshi Asano1, Chie Kurosaki2, Yuko Mori3

  • 1Japan Pharmaceutical Manufacturers Association, Nihonbashi Life Science Bldg, 2-3-11 Nihonbashi-honcho, Chuo-Ku, Tokyo, Japan; Teijin Pharma Limited, Toxicology & DMPK Development Research Group, 4-3-2, Asahigaoka, Hino, Tokyo, 191-8512, Japan.

Drug metabolism and pharmacokinetics
|December 8, 2023
PubMed
概括

一个新的机械静态药理动力学模型准确地预测了药物运输体介导的药物药物相互作用 (DDI). 该模型显示高准确度,特别是对于他类药物,改善了DDI风险评估.

关键词:
DDI的指导/指导方针药物相互作用 (DDI) 是一种药物相互作用.机械静态药理动力学 (MSPK) 模型净效应MSPK模型的模型运输商 运输商 运输商

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