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在患有先天性隔膜的胎儿的胎盘中,血管反应性发生改变

Emily J J Horn-Oudshoorn¹, Michelle Broekhuizen², Madhavi S Harhangi³

¹Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Rotterdam, the Netherlands.

|December 8, 2023

概括

先天性隔膜 (CDH) 改变胎盘动脉,显示增加收缩和减少扩张. 胎盘中的这些血管变化可能有助于预测婴儿肺高血压治疗反应.

科学领域:

血管生物学血管生物学
发展生物学发展生物学
新生儿医学新生儿医学

背景情况:

患有先天性隔膜 (CDH) 的婴儿经常患有肺高血压.
肺血管活性在CDH中经常发生变化,导致血管扩展剂治疗的反应不佳.
在体内调查肺部变化是具有挑战性的.

研究的目的:

为了调查胎盘血管是否表现出类似的血管活性改变作为肺血管在CDH.
探索胎盘动脉作为预测CDH婴儿治疗反应的模型的潜力.

主要方法:

在健康和CDH受影响的胎盘中,使用线状肌图评估胎盘动脉功能.
使用定量PCR测量血管反应通路中关键酶和受体的表达.

主要成果:

CDH动脉对血栓素A2激动剂的收缩明显强烈,对布拉迪基宁和氧化 (NO) 供体的扩张减少.
甘酸环酶1溶性子单元α1和蛋白激酶循环甘单酸盐 (cGMP) 依赖性1的表达在CDH胎盘中降低.
对endothelin-1,iloprost, forskolin和固酶抑制剂的影响的反应没有显著不同.

结论:

胎盘动脉在CDH中表现出改变的血管活性,反映了肺血管结构的变化.
这些发现表明,胎盘动脉可以作为CDH婴儿肺部治疗反应的预测模型.

关键词:

动脉动脉的动脉是一种动脉.生产性腹膜带 Hernia 是一种先天性腹膜.氧化氧化是什么?胎盘胎盘胎盘胎盘血栓素是一种血管反应性血管反应性血管收缩是一种血管收缩.血管扩张是一种血管扩张.

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