从COVID-19中康复后的认知障碍:频率,概况和与临床和实验室指数的关系
Silvana Galderisi1, Andrea Perrottelli1, Luigi Giuliani1
1University of Campania Luigi Vanvitelli, Naples, Italy.
概括
认知障碍 (CI) 影响了超过三分之一的COVID-19幸存者,与疾病严重程度和心理健康问题有关. 常规的认知评估和潜在的培训建议受影响的患者.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 认知障碍 (CI) 是COVID-19幸存者的重要关注点,但其患病率,特征和与疾病严重程度的关联尚未完全理解.
- 了解COVID-19的长期认知影响对于开发有效的患者管理策略至关重要.
研究的目的:
- 调查COVID-19幸存者的大量队列中认知障碍的频率和概况.
- 探索认知障碍与COVID-19的临床/实验室标记以及精神病理特征之间的关系.
- 评估认知障碍对全球功能的影响.
主要方法:
- 一项两阶段的研究涉及面对面查工具,随后在COVID-19康复患者中进行综合神经认知测试电池 (MCCB).
- 评估临床和实验室指数,精神病理特征和全球功能.
- 神经认知表现与疾病相关因素之间的相关性分析.
主要成果:
- 超过三分之一的接受查的受试者表现出认知障碍 (COG+),与年龄较大,教育程度较低,男性性别,COVID-19严重程度和急性症状如厌氧和呼吸障碍有关.
- COG+受试者报告了更高的抑郁,焦虑和创伤后压力,全球功能更差.
- 该MCCB在45%的参与者中发现了CI,影响了注意力,记忆,学习和推理. 神经认知功能与LDH水平相反相关.
结论:
- 认知障碍在COVID-19幸存者中普遍存在,并与疾病严重程度和心理困扰有关.
- 建议对COVID-19患者进行常规认知评估,特别是老年人和有严重症状的人.
- 应考虑认知培训计划来管理COVID-19后持续的认知功能障碍.
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