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多药耐药性在一只流浪狗中的Trichophyton indotineae

Vahid Oladzad¹, Ayatollah Nasrollahi Omran¹, Iman Haghani²

¹Department of Mycology, Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

Research in veterinary science

|December 8, 2023

概括

一只感染Trichophyton indotineae的狗表现出多药耐药的真菌感染. 这项研究确定了可能导致对特尔比纳耐药性的特定基因突变,突出了治疗皮肤植物病的新挑战.

科学领域:

兽医真菌学兽医真菌学
抗微生物耐药性抗微生物耐药性
分子诊断学分子诊断

背景情况:

皮肤植物病是一种常见的动物真菌感染,通常是由Trichophyton物种引起的.
新兴的抗真菌耐药性对这些感染的有效治疗构成重大威胁.
三植物 (Trichophyton indotineae) 是各种宿主中皮肤植物病的新兴原因.

研究的目的:

为了确定狗狗皮肤植物病的致病原体.
为了确定隔离的真菌的抗真菌敏感性概况.
研究抗真菌耐药性的潜在遗传机制.

主要方法:

使用内部转录间隔器 (ITS) 区域的测序来识别真菌.
根据临床和实验室标准研究所 (CLSI) M38-A3指南进行抗真菌敏感性测试.
测序squalene epoxidase (SQLE) 基因以识别与耐药性相关的突变.

主要成果:

病因因子被确定为Trichophyton indotineae. 这个病因因.
隔离物表现出对特比纳和伊特拉可纳 (MIC≥16μg/mL) 具有多药耐药性的表型.
观察到卢利可纳的体外活性 (MIC = 0.016μg/mL).
测序揭示了SQLE基因中的Phe397Leu和Ala448Thr替代物,可能会产生对特尔比纳芬的抗性.

结论:

这一案例突显了多药耐药的Trichophyton indotineae在兽医中的出现.
在SQLE基因中的特定突变与这种隔离物中的特尔比纳耐药性有关.
卢利可纳在体外显示有效性,表明其作为治疗选择的潜力.

关键词:

狗的皮肤植物病.流浪狗,多种药物耐药性特尔比纳芬 - 耐药性这种植物是Trichophyton indotineae.

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