GnRH类似物诱导LH峰值并增加母羊每定时AI的怀孕
Raquel Grande Pereira1, Otávio Saraiva Pires2, Clério Antônio Hoefle1
1Universidade do Estado de Santa Catarina, Chapecó, SC, Brazil.
Theriogenology
|December 8, 2023
概括
这项研究评估了激素释放激素 (GnRH) 的类似物,用于诱导绵羊的黄素化激素 (LH) 释放. 布塞雷林酸盐,莱西瑞林和德斯洛雷林与淋巴激素相比,表现出更好的LH诱导,而布塞雷林酸盐在定时人工授精中也改善了怀孕率.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
背景情况:
- 有限的研究存在于GnRH模拟对诱导绵羊LH激增的疗效.
- 了解最佳的GnRH类似物和剂量对于提高羊的繁殖效率至关重要.
研究的目的:
- 评估不同GnRH类型和剂量的LH释放诱导能力.
- 评估GnRH在定时人工授精 (TAI) 期间给药对怀孕率的影响.
主要方法:
- 实验1:绵羊接受了美德酸 (MPA) 和前列腺素F2α,然后在不同的剂量中接受了各种GnRH类似物 (莱西瑞林,冈多瑞林,布塞瑞林酸,德斯洛雷林). 对LH水平进行了监测.
- 实验2:用MPA治疗的绵羊在TAI接受了布塞雷林酸盐或没有治疗. 怀孕率进行了比较.
主要成果:
- 布塞瑞林乙酸 (8.4微克),莱西瑞林 (12.5和25微克) 和德斯洛雷林 (375和750微克) 诱导的LH度明显高于冈多雷林.
- 对4.2微克布塞雷林酸盐的LH反应与100微克冈纳多林相比.
- 与对照组 (40.7%) 相比,用布塞雷林酸盐治疗的母羊每次TAI的怀孕率更高 (50.3%).
结论:
- 布塞雷林酸,莱西瑞林和德斯洛雷林是有效的GnRH类似物,用于诱导母羊的LH分泌.
- 在TAI中使用布塞雷林酸盐可以提高与MPA和eCG同步的母羊的妊娠结果.
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