呼吸室:迈向下一代气管道工程
Alexandra A Dumas1, Ryan M Friedman1, Kyra W Y Smith1
1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Surgery, Division of Otolaryngology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Cell stem cell
|December 8, 2023
概括
工程气管发育是具有挑战性的. 一种新的堆叠环方法成功地保持了子气管的通透性8周,为气管再生提供了一个有希望的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 为临床使用创造具有足够机械强度和细胞特征的功能性工程气管是一个重大障碍.
- 现有的方法难以复制本地气管组织的复杂结构和机械完整性.
研究的目的:
- 开发和评估一种新的堆叠生物材料方法,用于工程气管段.
- 在临床前模型中评估工程气管的整合性,通透性和机械稳定性.
主要方法:
- 采用了堆叠的施工方法,在软骨和纤维环材料之间交替使用.
- 工程气管段经过手术植入子.
- 在8周的时间内进行了整合,通透性和组织反应的评估.
主要成果:
- 工程化气管段在宿主组织中成功集成.
- 在整个8周的观察期内,气管通透性保持不变.
- 堆叠的环设计提供了结构支持,并促进了组织的保留.
结论:
- 建议的交替的软骨和纤维状环的堆叠方法是工程气管段的可行策略.
- 这种方法显示出产生功能性气管替代体的前景,在体内具有持续的通透性.
- 进一步的研究可以探索长期结果和临床翻译的可扩展性.
相关概念视频
Trachea
2.1K
The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
2.1K
Tracheostomy: Procedure and Tubes
620
A tracheostomy is a surgical procedure that creates an artificial opening into the trachea, typically at the second or third cartilaginous ring level. This opening allows the insertion of a tracheostomy tube, which can replace an endotracheal tube, provide mechanical ventilation, bypass an upper airway obstruction, or remove accumulated tracheobronchial secretions.
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
620
Oxygen Delivering System III: Tracheostomy and T-piece
1.0K
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
1.0K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
614
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
614
Tracheostomy Decannulation
185
Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
185
Tracheostomy Care I: Pre-procedural Steps
196
A tracheostomy is a surgical technique that involves making an incision in the neck to provide access to the trachea. It is frequently used in medical conditions such as airway obstruction and prolonged mechanical ventilation. Effective nursing management is crucial for the long-term success of a tracheostomy.
Required Equipment
The equipment necessary for tracheostomy care includes:
Required Equipment
The equipment necessary for tracheostomy care includes:
196


