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相关概念视频

Genomics02:02

Genomics

36.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Genetic Material01:20

Genetic Material

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Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
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相关实验视频

Updated: Jul 9, 2025

Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

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一个统计,无参考的基因组算法统一了生物发现

Kaitlin Chaung1, Tavor Z Baharav2, George Henderson1

  • 1Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.

Cell
|December 8, 2023
PubMed
概括
此摘要是机器生成的。

介绍SPLASH (统计初级aLignment不可知序列定位),一种分析原始序列数据的新基因组学方法. 这种方法绕过参考基因组直接识别序列变异,从而实现更广泛的生物发现.

关键词:
在RNA-seq计算生物学遗传学基因组学没有参考一个细胞RNA-seq接合方式统计数据

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Last Updated: Jul 9, 2025

Novel Sequence Discovery by Subtractive Genomics
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Novel Sequence Discovery by Subtractive Genomics

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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

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科学领域:

  • 基因组学
  • 生物信息学
  • 计算生物学

背景情况:

  • 目前的基因组工作流程依赖于参考序列,限制了新生物见解的发现.
  • 基于参考的分析与复杂的变异和非模型生物进行斗争.

研究的目的:

  • 作为基因组分析的统一范式,介绍SPLASH (统计初级aLignment不可知序列定位).
  • 允许对原始测序数据进行直接分析,以识别没有参考基因组的样本特异性测序变化.

主要方法:

  • SPLASH使用统计测试直接分析原始测序数据.
  • 该方法旨在实现可扩展性,并检测各种类型的序列变化.
  • 不需要依赖元数据或参考基因组.

主要成果:

  • SPLASH 在 SARS-CoV-2 中发现了复杂的突变模式.
  • 在单细胞水平上发现调节的RNA异型.
  • 在非模型生物体中检测到适应性免疫受体多样性和新发现的生物学特征,包括环境和组织特异性变异.

结论:

  • SPLASH提供了一个统一的基因组分析方法,扩大了发现潜力.
  • 这种方法使生物系统的探索更加容易,不论基因组的可用性如何.
  • 能够对遗传和监管变异进行可扩展的,参考无关的发现.