安全性和疗效的比较:MemoLefort与左心房附属体关闭的守望者相比
Ling Li1, Sang Qian1, Jia-Yang Fu1
1Department of Cardiology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
International journal of cardiology
|December 8, 2023
概括
与Watchman设备相比,新的MemoLefort设备用于心房动 (AF) 患者的左心房关闭 (LAAC) 显示出类似的短期安全性和有效性. 这表明MemoLefort是LAAC程序的可行替代方案.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 干预心脏病学 干预心脏病学
背景情况:
- 心房动 (AF) 构成中风风险,通常通过抗凝药或左心房尾关闭 (LAAC) 进行治疗.
- MemoLefort插头封闭器是LAAC的一种新型设备,需要与Watchman封闭器等既有技术进行比较.
研究的目的:
- 为了比较MemoLefort遮器与LAAC的Watchman遮器在AF患者中的安全性和有效性.
- 评估主要安全性终点 (主要并发症,出血) 和主要疗效终点 (中风,栓塞,死亡).
主要方法:
- 一项队列研究包括189名连续接受MemoLefort或Watchman设备LAAC的患者.
- 在中位随访期内,患者的周围手术并发症,严重出血,中风,全身栓塞和心血管死亡情况进行了比较.
主要成果:
- 在初级疗效终点上没有发现显著差异 (4.1%的MemoLefort与2.1%的Watchman相比;P=0.68).
- 主要安全终点也没有显著差异 (2.0%MemoLefort与5.2%Watchman;P=0.19).
- 联合危险终点在MemoLefort和Watchman组之间也是相似的.
结论:
- 短期数据表明,MemoLefort LAAC的疗效和安全性与Watchman相似.
- MemoLefort显示了类似的临床净益处,将其定位为LAAC的可行替代品.
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