切割压力作为蛋白质基础疗法降解的驱动因素:比罪祸首更多的同谋

Camilla Moino1, Fiora Artusio1, Roberto Pisano1

  • 1Department of Applied Science and Technology, Politecnico di Torino, 24 Corso Duca degli Abruzzi, Torino 10129, Italy.

概括

由于剪切应力的蛋白质降解会影响治疗疗效和患者安全. 本综述详细介绍了在制药加工过程中切割应力对蛋白质稳定性的影响,并提供了缓解策略.

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