组织内存T细胞在人体生理和病理鼻腔粘膜中表现为表型和功能异质
Sifei Yu1, Kai Wang2, Chen Cao3
1Institute of translational medicine, The First People's Hospital of Foshan, 81 Lingnan Road, Foshan 528000, PR China.
Clinical immunology (Orlando, Fla.)
|December 8, 2023
概括
组织内存T细胞 (TRM) 对于粘膜免疫至关重要. 这项研究揭示了鼻组织中两个不同的TRM子集,影响慢性鼻炎与鼻息肉 (CRSwNPs) 和鼻逆转乳头瘤 (SNIP).
科学领域:
- 免疫学 免疫学 免疫学
- 粘膜免疫力 粘膜免疫力
- T细胞生物学T细胞生物学
背景情况:
- 组织内存T细胞 (TRM) 对于粘膜体对病原体的防御至关重要.
- 鼻腔粘膜中TRM细胞的特定免疫作用在很大程度上仍未被探索.
- 了解鼻腔TRM细胞子集对于解决鼻腔疾病至关重要.
研究的目的:
- 研究人类鼻腔粘膜中TRM细胞子集的特征和功能.
- 为了确定TRM细胞在CRSwNPs和SNIP等炎症性鼻腔疾病中的参与.
- 阐明鼻腔TRM子集之间的表型和功能区别.
主要方法:
- 在健康对照,CRSwNP和SNIP组织中对TRM细胞群 (CD103+和CD103-) 的比较分析.
- 评估细胞因子的产生,效应分子 (Granzyme B) 和免疫检查点表达 (PD-1,IL-10).
- 在体外研究中,使用CRSwNP同质物诱导CD103表达并评估T细胞反应,包括TGF-β抑制和对黄金葡萄球菌肠毒素B (SEB) 的反应.
主要成果:
- 与对照组相比,在CRSwNP和SNIP中观察到CD103+ TRM细胞的频率降低.
- 在CRSwNPs中的CD103+TRM细胞显示高效应细胞因子和Granzyme B生产,共同表达PD-1.
- CD103- TRM细胞主要产生IL-10;CRSwNP同质基因通过TGF-β诱导CD103的表达.
- CD103+ TRM细胞水平与中性粒细胞透在CRSwNPs中负相关.
- CD103+来自* Staphylococcus aureus*-阳性CRSwNP的TRM细胞表现出对SEB的增强反应.
结论:
- 由CD103表达定义的两个不同的鼻TRM细胞子集,具有独特的表型和功能.
- 这些TRM子集在CRSwNPs和SNIP的发病过程中起着重要的作用.
- 针对这些TRM细胞子集可能为鼻炎症疾病提供治疗策略.
相关概念视频
Cells of the Adaptive Immune Response
994
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
994
T Cell Activation and Clonal Selection
741
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
741
Immunological Memory
624
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
624
Cell-mediated Immune Responses
68.3K
Overview
68.3K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K


