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肠道微生物群:免疫检查点的双刃剑阻断免疫疗法对抗瘤

Juanjuan Wang¹, Ningning Zhu¹, Xiaomin Su¹

¹Translational Medicine Institute, Affiliated Tianjin Union Medical Center of Nankai University, Nankai University, Tianjin, 300071, China; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, 300071, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.

|December 8, 2023

概括

肠道微生物群影响癌症免疫疗法反应. 了解它的作用可以帮助提高免疫检查点阻塞 (ICB) 对更多患者的有效性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
微生物组研究微生物组研究

背景情况:

瘤细胞通过免疫检查点连接体逃避免疫监测,导致免疫细胞失活.
免疫检查点阻塞 (ICBs) 提高了癌症患者的生存率,但表现出异质的反应.
肠道微生物群越来越多地被认为具有克服对ICB免疫疗法的抵抗的能力.

研究的目的:

审查肠道微生物群在调节对瘤的免疫反应中的双重作用.
探索肠道微生物群如何提高ICB免疫疗法的疗效.
突出针对肠道微生物群的潜力,以改善癌症治疗.

主要方法:

关于研究肠道微生物群对瘤免疫和ICB治疗的影响的文献综述.
分析肠道微生物群衍生产品影响免疫细胞和瘤细胞的机制.
综合当前关于促进ICB反应的细菌物种的知识.

主要成果:

肠道微生物群起着复杂的作用,可能抑制或增强抗瘤免疫力.
特定的细菌物种及其代谢物 (例如,SCFA,Trp,BA) 可以促进有利的免疫反应.
来自微生物群的产品会影响免疫恒温和免疫抑制和炎症细胞的功能.

结论:

肠道微生物群是影响ICB免疫疗法的有效性的关键因素.
针对肠道微生物群提供了一种有希望的策略,以克服耐药性并改善癌症免疫治疗患者的结果.
对肠道微生物群-癌症免疫治疗轴的进一步研究可以促进治疗的发展.

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