在AARS-CoV-2感染后患有缺血性中风的患者中,内分泌小血栓的高频率
P Gómez-Porro1, B Cabal-Paz1, S Valenzuela-Chamorro1
1Servicio de Neurología, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
Neurologia
|December 8, 2023
概括
COVID-19 (2019年冠状病毒病) 可以导致缺血性中风,主要是由于带有内膜性血栓的动脉瘤. 这项研究强调COVID-19相关的凝血病是中风发展的关键因素.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 心血管医学 心血管医学
背景情况:
- 缺血性中风是SARS-CoV-2感染的重要并发症.
- 了解COVID-19患者中风亚型和结果对于管理至关重要.
研究的目的:
- 描述COVID-19患者缺血性中风的病因亚型,临床特征和结果.
- 为了调查COVID-19相关的凝血病在中风病原发生中的作用.
主要方法:
- 对连续出现急性焦点脑缺血的COVID-19患者的回顾性分析.
- 纳入标准:2020年3月1日至4月19日期间被诊断患有COVID-19并患有缺血性中风的患者.
- 收集的数据包括中风类型,病因,临床分数,实验室标记和结果.
主要成果:
- 分析了16名患有缺血性中风的患者 (1.38%的COVID-19病例).
- 主要的病因是动脉血性中风 (56.3%),内膜性血栓是主要的亚型 (31.2%).
- 增加的D-二聚合物 (87.5%) 和C-反应蛋白 (81.2%) 是常见的;死亡率为44%.
结论:
- 动脉血症,特别是内膜性血栓,是COVID-19患者缺血性中风的最常见原因.
- 临床和实验室发现支持COVID-19相关的凝血病作为中风的关键机制.
- 这些发现有助于理解中风病理生理学和指导患者治疗.
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