酸盐和Cissus quandrangularis涂层对植入物在子中的骨质整合的影响:一项临床前体内研究
Treasa Richa Roy1, Santosh Nelogi1, Ramesh Chowdhary2
1Department of Prosthodontics, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research (KLE University), Belagavi 590010, India.
Journal of stomatology, oral and maxillofacial surgery
|December 8, 2023
概括
一种新的Cissus quandrangularis酸盐凝 (CqChH) 涂层在第12周显著改善了植入物骨质整合. 这种表面处理增强了骨再生和新骨的形成,可能减少植入物治疗等待时间.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 再生医学是一种再生医学.
背景情况:
- (Ti) 植入物面临着长时间骨整合周期的挑战,影响患者的治疗坚持.
- 表面修改的Ti植入物提供了增强的骨质整合和早期加载的可能性.
- 新的水凝涂层正在探索,以加速植入物愈合.
研究的目的:
- 为了评估Ti植入物的骨质整合,涂上了一个新的Cissus quandrangularis奇托水凝 (CqChH).
- 为了比较CqChH涂层Ti植入物与商业纯 (Cp) Ti植入物在子模型中的性能.
主要方法:
- 24个CP Ti植入物被分为测试 (CqChH涂层) 和控制 (Cp) 组 (每组n=12).
- 植入物被放置在子的股骨和骨头中,植入物稳定率 (ISQ) 测量在6周和12周.
- 移除扭矩系数 (RTQ) 和组织病理学分析是在牺牲后进行的.
主要成果:
- 在6周后,ISQ或RTQ在两组之间没有显著差异.
- 在12周后,CqChH涂层的植入物与CP植入物相比显示出显著更高的ISQ (73.91±4.39) 和RTQ (75.96±14.10).
- 组织学分析表明,用CqChH涂层增强了骨再生和新骨的形成.
结论:
- 新的CqChH水凝涂层显著增强了Ti植入物的骨质整合.
- 与未涂层植入物相比,涂层促进了优质的骨再生和新骨形成.
- CqChH涂层的Ti植入物显示出加速牙科和骨科植入物治疗的希望.
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