评估风险偏好和情绪障碍之间的双向关系:一个双样本的门德尔随机化研究
Weilong Guo1, Yixin Zhao1, Jin Liu1
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Journal of affective disorders
|December 8, 2023
概括
风险偏好与双相情感障碍 (BP) 密切相关. 然而,风险偏好和严重抑郁症 (MDD) 之间没有发现显著的关联.
科学领域:
- 精神病学基因组学 精神病学基因学
- 行为遗传学 行为遗传学
- 神经科学是一个神经科学.
背景情况:
- 风险偏好,即倾向于进行风险活动,越来越多地与情绪障碍有关.
- 风险偏好和情绪障碍之间的因果关系和方向性仍然不清楚.
研究的目的:
- 调查一般风险偏好与双相情感障碍 (BP) 和严重抑郁障碍 (MDD) 之间的因果关系.
- 利用大规模的全基因组关联研究 (GWAS) 数据和门德尔随机化 (MR) 分析来进行强有力的因果推断.
主要方法:
- 使用来自大型GWAS数据集的总结统计数据进行了MR分析 (英国生物银行,23andMe,精神病基因组学联盟).
- 利用加权中位数,反变量加权和MR-Egger方法来评估因果关系和检测性.
- 分析了来自939,908个人的风险偏好,BP的413,466,MDD的807,553个人的数据.
主要成果:
- 核磁共振分析显示,风险偏好和双相情感障碍 (BP) 之间存在显著的双向因果关系 (P < 0.001).
- 在风险偏好和严重抑郁症 (MDD) (P > 0.05) 之间没有观察到可靠的因果关系.
结论:
- 强有力的证据支持风险偏好和BP之间的相互关系,但不是MDD.
- 研究结果表明,风险偏好可能成为早期识别BP的潜在标志物.
- 降低高血压患者的风险偏好可能是一个有价值的治疗干预措施.
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